ThaumatinV1, Main, Exploration, bibRecord, 000247

Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin.

Identifieur interne : 000247 ( Main/Exploration ); précédent : 000246; suivant : 000248

Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin.

Auteurs : Poonam Gautam [Inde] ; Santosh Kumar Upadhyay ; Wazid Hassan ; Taruna Madan ; Ravi Sirdeshmukh ; Curam Sreenivasacharlu Sundaram ; Wasudev Namdeo Gade ; Seemi Farhat Basir ; Yogendra Singh ; Puranam Usha Sarma

Source :

Mycopathologia [ 1573-0832 ] ; 2011.

RBID : pubmed:21755315

Descripteurs français

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Artemisinins (pharmacology), Aspergillosis (microbiology), Aspergillus fumigatus (drug effects), Aspergillus fumigatus (genetics), Aspergillus fumigatus (metabolism), Cell Wall (drug effects), Coproporphyrinogen Oxidase (metabolism), Fungal Proteins (metabolism), Glucan Endo-1,3-beta-D-Glucosidase (metabolism), Itraconazole (pharmacology), Methyltransferases (drug effects), Microbial Sensitivity Tests (MeSH), Mitochondria (drug effects), Mitochondria (metabolism), Molecular Sequence Data (MeSH), NADH Dehydrogenase (metabolism), Oligonucleotide Array Sequence Analysis (MeSH), Oxidative Phosphorylation (MeSH), Proteome (MeSH), Spores, Fungal (drug effects), Transcriptome (drug effects).
MESH :
- chemical , drug effects : Methyltransferases.
- chemical , metabolism : Coproporphyrinogen Oxidase, Fungal Proteins, Glucan Endo-1,3-beta-D-Glucosidase, NADH Dehydrogenase.
- chemical , pharmacology : Antifungal Agents, Artemisinins, Itraconazole.
- drug effects : Aspergillus fumigatus, Cell Wall, Mitochondria, Spores, Fungal, Transcriptome.
- genetics : Aspergillus fumigatus.
- metabolism : Aspergillus fumigatus, Mitochondria.
- microbiology : Aspergillosis.
- Microbial Sensitivity Tests, Molecular Sequence Data, Oligonucleotide Array Sequence Analysis, Oxidative Phosphorylation, Proteome.

Abstract

Artemisinin, an antimalarial drug, and its derivatives are reported to have antifungal activity against some fungi. We report its antifungal activity against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans, and its synergistic effect in combination with itraconazole (ITC), an available antifungal drug. In order to identify its molecular targets, we further analyzed transcript and proteomic profiles of the fungus on exposure to the artemisinin. In transcriptomic analysis, a total of 745 genes were observed to be modulated on exposure to artemisinin, and some of them were confirmed by real-time polymerase chain reaction analysis. Proteomic profiles of A. fumigatus treated with artemisinin showed modulation of 175 proteins (66 upregulated and 109 downregulated) as compared to the control. Peptide mass fingerprinting led to the identification of 85 proteins-29 upregulated and 56 downregulated, 65 of which were unique proteins. Consistent with earlier reports of molecular mechanisms of artemisinin and that of other antifungal drugs, we believe that oxidative phosphorylation pathway (64 kDa mitochondrial NADH dehydrogenase), cell wall-associated proteins and enzymes (conidial hydrophobin B protein, cell wall phiA protein, extracellular thaumatin domain protein, 1,3-beta-glucanosyltransferase Gel2) and genes involved in ergosterol biosynthesis (ERG6 and coproporphyrinogen III oxidase, HEM13) are potential targets of artemisinin for further investigations.

DOI: 10.1007/s11046-011-9445-3
PubMed: 21755315

Affiliations:

Inde

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000252
to stream Main, to step Curation: 000252

Le document en format XML

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<term>Aspergillus fumigatus (drug effects)</term>
<term>Aspergillus fumigatus (genetics)</term>
<term>Aspergillus fumigatus (metabolism)</term>
<term>Cell Wall (drug effects)</term>
<term>Coproporphyrinogen Oxidase (metabolism)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Glucan Endo-1,3-beta-D-Glucosidase (metabolism)</term>
<term>Itraconazole (pharmacology)</term>
<term>Methyltransferases (drug effects)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Mitochondria (drug effects)</term>
<term>Mitochondria (metabolism)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>NADH Dehydrogenase (metabolism)</term>
<term>Oligonucleotide Array Sequence Analysis (MeSH)</term>
<term>Oxidative Phosphorylation (MeSH)</term>
<term>Proteome (MeSH)</term>
<term>Spores, Fungal (drug effects)</term>
<term>Transcriptome (drug effects)</term>
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<term>Aspergillose (microbiologie)</term>
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<term>Aspergillus fumigatus (génétique)</term>
<term>Aspergillus fumigatus (métabolisme)</term>
<term>Coproporphyrinogen oxidase (métabolisme)</term>
<term>Données de séquences moléculaires (MeSH)</term>
<term>Glucan endo-1,3-beta-glucosidase (métabolisme)</term>
<term>Itraconazole (pharmacologie)</term>
<term>Methyltransferases (effets des médicaments et des substances chimiques)</term>
<term>Mitochondries (effets des médicaments et des substances chimiques)</term>
<term>Mitochondries (métabolisme)</term>
<term>NADH dehydrogenase (métabolisme)</term>
<term>Paroi cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Phosphorylation oxydative (MeSH)</term>
<term>Protéines fongiques (métabolisme)</term>
<term>Protéome (MeSH)</term>
<term>Spores fongiques (effets des médicaments et des substances chimiques)</term>
<term>Séquençage par oligonucléotides en batterie (MeSH)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
<term>Transcriptome (effets des médicaments et des substances chimiques)</term>
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<term>Artemisinins</term>
<term>Itraconazole</term>
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<term>Cell Wall</term>
<term>Mitochondria</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Aspergillus fumigatus</term>
<term>Methyltransferases</term>
<term>Mitochondries</term>
<term>Paroi cellulaire</term>
<term>Spores fongiques</term>
<term>Transcriptome</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aspergillus fumigatus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aspergillus fumigatus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aspergillus fumigatus</term>
<term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Aspergillose</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Aspergillosis</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Aspergillus fumigatus</term>
<term>Coproporphyrinogen oxidase</term>
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<term>Mitochondries</term>
<term>NADH dehydrogenase</term>
<term>Protéines fongiques</term>
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<term>Artémisinines</term>
<term>Itraconazole</term>
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<keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term>
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<term>Proteome</term>
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<term>Phosphorylation oxydative</term>
<term>Protéome</term>
<term>Séquençage par oligonucléotides en batterie</term>
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<front><div type="abstract" xml:lang="en">Artemisinin, an antimalarial drug, and its derivatives are reported to have antifungal activity against some fungi. We report its antifungal activity against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans, and its synergistic effect in combination with itraconazole (ITC), an available antifungal drug. In order to identify its molecular targets, we further analyzed transcript and proteomic profiles of the fungus on exposure to the artemisinin. In transcriptomic analysis, a total of 745 genes were observed to be modulated on exposure to artemisinin, and some of them were confirmed by real-time polymerase chain reaction analysis. Proteomic profiles of A. fumigatus treated with artemisinin showed modulation of 175 proteins (66 upregulated and 109 downregulated) as compared to the control. Peptide mass fingerprinting led to the identification of 85 proteins-29 upregulated and 56 downregulated, 65 of which were unique proteins. Consistent with earlier reports of molecular mechanisms of artemisinin and that of other antifungal drugs, we believe that oxidative phosphorylation pathway (64 kDa mitochondrial NADH dehydrogenase), cell wall-associated proteins and enzymes (conidial hydrophobin B protein, cell wall phiA protein, extracellular thaumatin domain protein, 1,3-beta-glucanosyltransferase Gel2) and genes involved in ergosterol biosynthesis (ERG6 and coproporphyrinogen III oxidase, HEM13) are potential targets of artemisinin for further investigations.</div>
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<Abstract><AbstractText>Artemisinin, an antimalarial drug, and its derivatives are reported to have antifungal activity against some fungi. We report its antifungal activity against Aspergillus fumigatus (A. fumigatus), a pathogenic filamentous fungus responsible for allergic and invasive aspergillosis in humans, and its synergistic effect in combination with itraconazole (ITC), an available antifungal drug. In order to identify its molecular targets, we further analyzed transcript and proteomic profiles of the fungus on exposure to the artemisinin. In transcriptomic analysis, a total of 745 genes were observed to be modulated on exposure to artemisinin, and some of them were confirmed by real-time polymerase chain reaction analysis. Proteomic profiles of A. fumigatus treated with artemisinin showed modulation of 175 proteins (66 upregulated and 109 downregulated) as compared to the control. Peptide mass fingerprinting led to the identification of 85 proteins-29 upregulated and 56 downregulated, 65 of which were unique proteins. Consistent with earlier reports of molecular mechanisms of artemisinin and that of other antifungal drugs, we believe that oxidative phosphorylation pathway (64 kDa mitochondrial NADH dehydrogenase), cell wall-associated proteins and enzymes (conidial hydrophobin B protein, cell wall phiA protein, extracellular thaumatin domain protein, 1,3-beta-glucanosyltransferase Gel2) and genes involved in ergosterol biosynthesis (ERG6 and coproporphyrinogen III oxidase, HEM13) are potential targets of artemisinin for further investigations.</AbstractText>
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<ForeName>Taruna</ForeName>
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<ForeName>Curam Sreenivasacharlu</ForeName>
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<ForeName>Wasudev Namdeo</ForeName>
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<ForeName>Seemi Farhat</ForeName>
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<ForeName>Yogendra</ForeName>
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Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin.

Transcriptomic and proteomic profile of Aspergillus fumigatus on exposure to artemisinin.

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